The administration of vitamin K is frequently guided by the International Normalized Ratio (INR), a standardized measurement of blood clotting time. Elevated INR values, often indicative of impaired coagulation, may necessitate vitamin K supplementation to restore normal clotting function. For example, an individual on warfarin therapy with an INR significantly above the therapeutic range may require vitamin K to counteract the anticoagulant effect.
Correcting an elevated INR through vitamin K administration offers the potential to reduce the risk of bleeding complications. Historically, vitamin K has been recognized for its crucial role in the synthesis of clotting factors within the liver. Its judicious use can prevent or manage excessive anticoagulation, which is particularly important in patients at risk of hemorrhage.